Women are falling victim to a 'killer heels con', with copies of famous brands reportedly flooding the internet. Websites with UK addresses claiming to offer genuine Christian Louboutin shoes, Jimmy Choos and Manolo Blahnik are at the centre of an international scam worth millions. The designer labels says there has been an explosion in the number of website scams in the past six months. Copy cats: The real Louboutin 'Pigalle', as worn by Kate Moss, usually costs £375 and below the fake which retails at £116.99. Rihanna wears a pair of £504 Louboutin 'Python Pumps' and below the £143.99 fake copies The boss of Paris-based Louboutin warned that both sellers and purchasers could be prosecuted. Genuine Louboutin shoes as worn by Sarah Jessica Parker, Victoria Beckham, Megan Fox and Halle Berry cab cost more than £400 a pair. The designs, with their fashionable killer heels, have reached mythical status among the legions of women desperate to emulate these style icons.

Such is the demand that criminal gangs, using factories in China, have set up websites they claim are operated by the owners of these prestige brands. They use images of what appear to be the genuine article. The Louboutin copies use the red soles, which are the signature of the renowned brand. Kate Moss and Kim Kardashian are among a number of celebrities seen wearing the Louboutin Pigalle Pumps, described as 'sexy', 'gorgeous' and 'fun', which would normally sell for £435. sells what it claims are the genuine article for £129.99 - a supposed saving of  70 per cent. Not the real deal: A fake pair of Christian Louboutin open-toed Leopard Hidden-Platform pump shoes and below Christina Aguilera and Denise Richards in the original shoes The website falsely claims the shoes are manufactured by Christian Louboutin in Italy, while it boasts they are '100 per cent Authentic' and 'Quality Guaranteed'. Sarah Jessica Parker, whose Carrie Bradshaw character in the hit TV series Sex and the City turned a love of shoes into a fashion fetish, has been pictured wearing the Louboutin Very Galaxy shoes.

The mirror metallic shoes in a fiery fuchsia sell for £453. However, the fakes are marked at £131.99, which the website falsely claims is a saving of 71per cent. There are many other examples of Louboutin fakes, including the open-toed Leopard Hidden-Platform pump  and a black platform pump. website presents itself as a genuine authorised web store. It claims the prices are so cheap because the shoes come 'straight from the production line'. It fuels the hype around its shoes by boasting: 'The world is talking about Christian Louboutin, and the Hollywood stars lead the fashion. It is time to get yourself some.' to sell fake Louboutin shoes Louboutin chief operating officer Alexis Mourot told the Daily Mail: 'This has changed from being a minimal problem to a flood, in terms of these fake websites, in just the last six months. 'It is all coming out of China. These are not small workshops. This is organised and the money is going to criminals, the Mafia.'

Mr Mourot said: 'Some people may think it is good to be able to buy cheap copies, but we would say this is definitely not cool, it is criminal.' The company is working with customs in the UK and France to identify the purchasers and sellers. Some websites has also been shut down following talks with large internet operators, however they are quickly replaced with similar new names.nike shoes pics 2014 Mr Mourot added: 'The quality in terms of the leather, the heels and stitching is very poor on the copies compared to the genuine shoes, which are made in Italy by craftsmen.'nike mens shoes casual It also provides a list of official stockists and asks the public to report criminals selling fake merchandise.best nike shoes for basketball 2013

, which offers a free weekly email service identifying the ten best fashion finds on the internet. These will be genuine must-have items at bargain prices. A website spokesman for BragItUp said:  'At first look these sites look genuine, each packed with pages and pages of images of Louboutin shoes with prices slashed by at least 50per cent.big nike shoe box for sale 'To reassure the customer, the sites all offer free shipping and no tax, the sites are stamped with money back guarantees and a multitude of payment options and prices are available in a number of currencies.boat shoes uk sale 'But there are a number of tell-tale signs that these deals are too good to be true.nike shoes price and pics 'There’s a repetitive theme about safety of online shopping, the copy is littered with grammatical and linguistic mistakes.

'Also, contact is via email only. It is very rare to find a telephone number.'Steve Gschmeissner/Science Photo Library The first time molecular biologist Greg Hannon flew through a tumour, he was astonished — and inspired. Using a virtual-reality model, Hannon and his colleagues at the University of Cambridge, UK, flew in and out of blood vessels, took stock of infiltrating immune cells and hatched an idea for an unprecedented tumour atlas. “Holy crap!” he recalls thinking. “This is going to be just amazing.” On 10 February, the London-based charity Cancer Research UK announced that Hannon’s team of molecular biologists, astronomers and game designers would receive up to £20 million (US$25 million) over the next five years to develop its interactive virtual-reality map of breast cancers. The tumour that Hannon flew through was a mock-up, but the real models will include data on the expression of thousands of genes and dozens of proteins in each cell of a tumour.

The hope is that this spatial and functional detail could reveal more about the factors that influence a tumour’s response to treatment. The project is just one of a string that aims to build a new generation of cell atlases: maps of organs or tumours that describe location and make-up of each cell in painstaking detail. Cancer Research UK awarded another team up to £16 million to make a similar tumour map that will focus on metabolites and proteins. Later this year, the US National Institute of Mental Health will announce the winners of grants to map mouse brains in extraordinary molecular detail. And on 23–24 February, researchers will gather at Stanford University in California to continue planning the Human Cell Atlas, an as-yet-unfunded effort to map every cell in the human body. “This is a very hot topic,” says Ido Amit, who studies the genomics of the immune system at the Weizmann Institute of Science in Rehovot, Israel. “It’s all location, location, location.

The community knows this has to be the next step.” Over the past few years, researchers have flocked to techniques that allow them to sequence the full complement of RNAs — tens of thousands of them — in individual cells. These RNAs can reveal which genes are expressed, and provide clues as to a cell’s unique function within an organ or tumour. But sequencing methods typically require that the cells first be plucked from the tissue in which they live. That destroys valuable information about where the cells were and what neighbours they interacted with — information that could hold new clues to a cell’s function and how it can go awry in diseased tissue. “There is a lot of excitement and promise with single-cell sequencing technologies,” says Nicola Crosetto, a molecular biologist at the Karolinska Institute in Stockholm. “But when we think of cancer and complex physiological tissues, we need to be able to put that information into spatial context.” Techniques are emerging to do so.

On 6 February, Amit and Shalev Itzkovitz, also at the Weizmann Institute, and their colleagues reported that they had created a cell-by-cell map of mouse liver lobules, complete with RNA sequences from each cell 1 . The lobules of the liver are conventionally divided into concentric layers; the team found unique gene-expression patterns in cells lying at the interface between two layers. “This region of the tissue is not just a transition zone,” says Itzkovitz. “It’s a new zone with a specified function.” Meanwhile, Hannon has teamed up with biophysicist Xiaowei Zhuang at Harvard University in Cambridge, Massachusetts, who has developed a method that encodes RNAs with binary barcodes that can be read within cells using imaging techniques. The technique detects thousands of RNAs in a single cell simultaneously, without dissociating it from its neighbours. “Every time I look at the images with the barcodes sticking out, it reminds me of the movie The Matrix,” Zhuang says.

The molecular cartography of RNA is simple in comparison to working with proteins and other molecules. Josephine Bunch of the National Physical Laboratory in Teddington, UK, and her colleagues are developing tumour atlases with detailed information about small molecules, such as lipids, drugs and metabolites, as well as large molecules such as proteins. The methods will allow her team to assess about 50 proteins per sample. That may sound less impressive than the thousands of RNAs measured by other techniques, but information about 50 proteins — which can be selected to suit specific tissues — present in different combinations is enough to identify major cell types and gauge key molecular pathways operating in them, says Garry Nolan, a molecular biologist at Stanford University. Proteins offer a more direct view into the function of a cell than does RNA, he notes, and can better allow researchers to link their data to previously published cell atlases dating back decades.